Blar i forfatter "Salem, Abdelhakim"

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    • The effect of interleukin-17F on vasculogenic mimicry in oral tongue squamous cell carcinoma 

      Almahmoudi, Rabeia; Salem, Abdelhakim; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Salo, Tuula; Al-Samadi, Ahmed (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-20)
      Oral tongue squamous cell carcinoma (OTSCC) is one of the most common cancers worldwide and is characterized by early metastasis and poor prognosis. Recently, we reported that extracellular interleukin-17F (IL-17F) correlates with better disease-specific survival in OTSCC patients and has promising anticancer effects in vitro. Vasculogenic mimicry (VM) is the formation of an alternative vasculogenic ...

    • Tumour cells express functional lymphatic endothelium-specific hyaluronan receptor in vitro and in vivo: Lymphatic mimicry promotes oral oncogenesis? 

      Karinen, Sini; Juurikka, Krista; Hujanen, Roosa; Whabi, Wafa; Hadler-Olsen, Elin Synnøve; Svineng, Gunbjørg; Eklund, Kari K.; Salo, Tuula; Åström, Pirjo; Salem, Abdelhakim (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-03-05)
      Lymphatic metastasis represents the main route of tumour cell dissemination in oral squamous cell carcinoma (OSCC). Yet, there are no FDA-approved therapeutics targeting cancer-related lymphangiogenesis to date. The lymphatic vessel endothelial hyaluronic acid receptor 1 (LYVE-1), a specific lymphatic marker, is associated with poor survival in OSCC patients. In this study, we present a potential ...